Restriction of Francisella novicida Genetic Diversity during Infection of the Vector Midgut

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Restriction of Francisella novicida Genetic Diversity during Infection of the Vector Midgut

The genetic diversity of pathogens, and interactions between genotypes, can strongly influence pathogen phenotypes such as transmissibility and virulence. For vector-borne pathogens, both mammalian hosts and arthropod vectors may limit pathogen genotypic diversity (number of unique genotypes circulating in an area) by preventing infection or transmission of particular genotypes. Mammalian hosts...

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Francisella tularensis is the causative agent of tularemia and is a category A select agent. Francisella novicida, considered by some to be one of four subspecies of F. tularensis, is used as a model in pathogenesis studies because it causes a disease similar to tularemia in rodents but is not harmful to humans. F. novicida exhibits a strong restriction barrier which reduces the transformation ...

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Recommended Citation Fayram, Drew Clair. "Characterization of the neutrophil respiratory burst during infection with Francisella novicida. has been approved by the Examining Committee for the thesis requirement for the Master of Science degree in Microbiology at the May 2013 graduation. ii To my parents, John and Marina, for fostering my passion for learning and for their endless love and suppo...

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ژورنال

عنوان ژورنال: PLoS Pathogens

سال: 2014

ISSN: 1553-7374

DOI: 10.1371/journal.ppat.1004499